Martine Dunnwald, PharmD, PhD

• Anatomical variations

Darren Hoffmann, PhD

• Use of anatomy simulations to improve student learning of gross anatomy
• Integration of massage therapy and anatomy for health professions students
• Training of graduate students and post-doctoral fellows for teaching roles
• Self-regulated learning and constructivist teaching/learning methods

Marc Pizzimenti, PhD

• Assessing the role of interactive teaching techniques in enhancing learning

Brad A. Amendt, PhD

Martine Dunnwald, PharmD, PhD

• Mechanisms of IRF6-mediated keratinocyte migration during wound healing

• Role of cleft-associated genes in wound healing and tissue repair

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John F. Engelhardt, PhD 

• Redox-mediated signal transduction pathways in disease
• Receptor signaling and endosomal control of NADPH oxidases

• Cell Biology of adeno-associated virus (AAV) transduction

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C. Andrew Frank, PhD

• Synaptic transmission and muscle-to-nerve retrograde signaling in Drosophila

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Masataka Kawai, PhD

• Molecular mechanisms of force generation in striated muscles
• Reconstitution of the thin filament in cardiac muscles
• Positive allosteric effect of tropomyosin on the actomysin interaction 

• Mechanisms of underlying hypertrophic cardiomyopathy (HCM) 

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Fang Lin, MD, PhD

• Involvement of G protein signaling in the migration of primordial germ cells (PGC)

• Identification of G proteins and G protein-coupled receptors that regulate gastrulation

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Tom Rutkowski, PhD

• Mechanisms by which cells adapt or succumb to chronic protein misfolding stresses

• Systems biology of the endoplasmic reticulum stress response—how integration of signals from distinct stress-sensing pathways brings about discrete changes in cellular physiology

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Tina Tootle, PhD

• Mechanisms of prostaglandin-mediated cytoskeleton remodeling during Drosophila oogenesis

• Border-cell migration as a model for understanding prostaglandin-mediated invasive cell migration

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Charles Yeaman, PhD

• Cellular mechanisms involved in development and maintenance of epithelial-cell polarity
• Roles of Ras-like GTPases and Exocyst in epithelial membrane trafficking
• Functions of primary cilia in regulating epithelial-cell growth and differentiation

Brad A. Amendt, PhD

• Mouse models for craniofacial anomalies
• Transcriptional gene networks for craniofacial and tooth development
• New approaches and mouse models for microRNA function

• The role of Hippo Signaling in craniofacial growth

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Botond Banfi, MD, PhD

• NADPH oxidase regulation in hair-cell development in the inner ear 

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Martine Dunnwald PharmD, PhD

• In vivo function of novel cleft-associated genes in craniofacial development

• Role of cleft-associated genes in epidermal development and differentiation

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John F. Engelhardt, PhD 

• Transcriptional control of submucosal-gland formation in the airway

• Somatic-cell reprogramming by nuclear transfer and the development of new genetic models

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C. Andrew Frank, PhD

• Development of the Drosophila neuromuscular junction in the context of unstable synaptic function

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Fang Lin, MD, PhD

• Investigation of G protein signaling in zebrafish embryogenesis

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 Tina Tootle, PhD

• Use of Drosophila, in particular oogenesis, to elucidate the molecular mechanisms underlying prostaglandin action

Brad A. Amendt, PhD

• microRNA gene therapies for tissue engineering
• Development of 3D printed scaffolds and gene therapies for cleft palate repair

• Bone and tissue regeneration using new microRNA biotechnologies

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Botand Banfi, MD, PhD

• Molecular mechanisms that underlying defects in cystic fibrosis and deafness, with a focus on ROS and NADPH oxidase

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Adam Dupuy, PhD

• Use of sleeping beauty transposon system to generate tissue specific-models of cancer in mice

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John F. Engelhardt, PhD

• Development of gene therapies for inherited and environmentally induced diseases
• Development of recombinant adeno-associated viral vectors for gene therapy
• Investigation of the pathogenesis and treatment of cystic fibrosis lung disease

• Mechanisms underlying ischemia/reperfusion injury and applications of gene therapy in the liver

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C. Andrew Frank, PhD

• Use of Drosophila genetics and pharmacology to understand signaling pathways that link synaptic instability to disorders of the nervous system

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Tom Rutkowski, PhD

• Mechanistic links between endoplasmic reticulum homeostasis and lipid metabolism in the liver

• Mechanisms whereby dysregulation of the ER stress response contributes to diseases of liver function (metabolic syndrome, hepatitis, alcohol steatosis)

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Ling Yang, PhD

• . Cellular and molecular mechanisms of Nonalcoholic fatty liver disease (NAFLD);
• . Organelle function in the context of obesity and diabetes;

• . The role of organelle stress responses in maintaining Immuno-metabolic homeostasis in cardiovascular diseases (CVDs)

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Charles Yeaman, PhD

• Molecular mechanisms underlying renal cystogenesis, with a focus on dysfunction of the primary cilia 

C. Andrew Frank, PhD

• Use of electrophysiology to understand the phenomenology and molecular mechanisms that underlie synaptic homeostasis, and the maintenance of stable synapse function

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Marc Pizzimenti, PhD

• Biomechanical implications of motor deficits on movement control as the result of stroke
• Delineating the degree to which recovery of movement is enhanced with treatment

Fang Lin, MD, PhD

• Use of zebrafish as a model to elucidate the functions of Gβγ/PI3Kγ in angiogenesis